
While national chains dominate much of the sandwich scene, some of the best subs, hoagies, and deli creations are found in regional gems you might never have even heard of, unless you live nearby. These local favorites boast bold flavors, inventive ingredients, and loyal fans who know they’re onto something special.
From quirky ordering systems to cultural specialties, these sandwich spots prove that there is life beyond the usual fast-food scene. If given the chance, they could win over hearts and stomachs across America. Let’s take a look at 14 regional sandwich chains that should be nationwide.
1. Which Wich

This chain is from Texas and has revolutionized the world of sandwich ordering with its creative customization. Fans of Which Wich love its quirky paper bag ordering system and endless ingredient choices. Despite its growing popularity, many people outside of Texas have never heard of this fresh take on subs yet.
2. Ike’s Love & Sandwiches

Ike’s Love & Sandwiches is known for its wildly inventive and oversized sandwiches. This spot’s cult following on the West Coast speaks volumes about its crave-worthy appeal. Some of its chains constantly face long lines, showing just how popular Ike’s Love & Sandwiches could be if it went nationwide.
3. Firehouse Subs

Firehouse Subs was founded by firefighters and has a loyal fan base thanks to its hearty sandwiches packed with quality meats and cheeses. Its community-focused vibe and commitment to safety and flavor make it a favorite spot in Florida. While it is well known in certain regions, many people haven’t even heard of it yet.
4. Togo’s

Togo’s, a favorite spot in Northern California, has been around since 1964, and focuses on freshly sliced meats and thick, homemade bread. This restaurant’s commitment to fresh ingredients and quality craftsmanship has shown to increase customer loyalty. It’s a spot everyone should try at least once.
5. Primo Hoagies

Introducing true Philadelphia-style hoagies to areas beyond Pennsylvania would help elevate regional cuisine across the country. Primo Hoagies are more than just sandwiches; they’re a flavorful part of cultural tradition. Growing this chain could enrich the nation’s food landscape and offer sandwich enthusiasts everywhere an authentic taste of the East Coast.
6. Penn Station East Coast Subs

Penn Station East Coast Subs is a Midwest favorite that is known for its freshly squeezed lemonade and made-to-order subs. This restaurant is casual and comfortable, the perfect breather in a fast-paced world.
7. Schlotzsky’s Austin Eatery

Schlotzsky’s was once a thriving national chain, but it has scaled back over the years. Many fans still argue that this chain offers unique sandwiches that are worth a comeback, blending sourdough buns and signature sauces. Its quirkiness may divide opinions, but it definitely sparks debate, proving it’s a chain that could surprise and delight a nationwide audience.
8. Mazzio’s Italian Eatery

Mazzio’s Italian Eatery might be better known for pizza, but this Midwest chain’s sandwiches are amazing. They offer Italian-inspired subs with bold flavors. Despite consistent good reviews, not many people know about this restaurant.
9. Jason’s Deli

This Southern-based chain stands out for its wide-ranging menu and a strong focus on healthy choices. As demand rises for fresh, nutritious fast-casual dining, Jason’s Deli is well-positioned to expand nationwide.
10. Lesters Di

Lesters Di is a Baltimore staple that is famous for its steamed sandwiches and distinctive crab-spiced meats. This hometown favorite captures the essence of Chesapeake Bay cuisine, combining rich tradition with bold, memorable flavors. With broader exposure, Lesters could introduce a delicious regional specialty to sandwich lovers nationwide.
11. Schtzsky’s

Schtzsky’s is known for its iconic sourdough buns and signature sauces, creating amazing sandwiches that stand out from typical sub shops. While its national presence has shrunk, its unique flavors and quirky vibe could find new fans across America and spark renewed interest in this restaurant if it is relaunched on a wider scale.
12. Fire Ice Deli

Fire & Ice Deli is a Denver favorite that is beloved for its hearty portions and adventurous flavors. Its loyal fans have stuck around due to its commitment to robust taste profiles and generous servings. This bold local gem has the potential to energize the national sandwich market with its distinctive style.
13. Mr. Sub

Mr. Sub is a Canadian-owned and operated chain that combines simple, satisfying sandwiches with consistent quality. The chain’s straightforward menu focuses on fresh ingredients and classic flavor combinations. If it were to cross into the U.S. market, it would likely become a new favorite.
14. Blimpie

Once a trailblazer in the world of submarine sandwiches, Blimpie carries a sense of nostalgia for many people, but it remains surprisingly underrepresented today. With its legacy and timeless menu, a refreshed national push could revive the brand, introducing its comforting, classic flavors to a new generation of sandwich lovers.